Arsenal's captain looks set to sign a new deal and end speculation over his future, and he will be key if the Gunners are to start the season with a win.
Aubameyang hit 29 goals in all competitions last season and he will want to find the net at Craven Cottage on Saturday as he looks to better his tally from 2019/20.
The Gabon international will continue to operate off the left-hand side, but Mikel Arteta will be keen to see Aubameyang get into central areas where he is most dangerous.
Signed on a free from Chelsea this summer, the experienced Brazilian adds a different attacking option to Arteta's squad.
Willian will be keen to impress on his debut but faces competition for a starting place from the likes of Nicolas Pepe, Bukayo Saka and Reiss Nelson.
The 32-year-old should help the Gunners create chances at Craven Cottage and go some way to rectifying the lack of creative spark they suffered from last season.
The Frenchman faces serious competition from Eddie Nketiah to lead the line for Arsenal this season, and he will want to impress on the opening day to stake his claim.
Lacazette scored twice at Craven Cottage two seasons ago and a similar display could guide the Gunners to an opening day win.
The striker will be keen to put a poor 2019/20 season behind him and make the perfect start to the new campaign against Fulham.