After scoring the winner against West Ham on Saturday, the youngster should be rewarded with a start against the Foxes.
Nketiah will have to rely on his clever movement to find spaces in behind and get the better of Leicester's physical defender Ça?lar Söyüncü
Arsenal must not allow the striker to become isolated, with support from midfield and out wide the key to success at the King Power.
Having been named as a substitute for both Premier League games so far this season, Arsenal's club-record signing is likely to start against Leicester.
Pepe could be up against Christian Fuchs if Foxes boss Brendan Rodgers decides to rest James Justin, and he will fancy his chances against the ageing Austrian left-back.
The Ivorian will be keen to impress and earn his place in the Premier League starting XI, with Willian and Bukayo Saka providing stiff competition for places.
Despite impressing in the opening day win over Fulham, the versatile Englishman was named on the bench against West Ham, but he should start on Tuesday.
Maitland-Niles could well reprise his inverted wing-back role from the victory at Craven Cottage, with his attacking in-field runs leading to confusion and chaos amongst the opposition defence.
It remains to be seen whether he will start on the left or the right, but Mikel Arteta will likely demand more of the same from the 23-year-old.